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The Arizona Cardinals will have to lean on James Conner out of the backfield for at least the next three weeks.

Cardinals running back Chase Edmonds suffered a high-ankle sprain, NFL Network Insider Ian Rapoport reported. An MRI confirmed the injury Monday morning. Edmonds is likely to land on injured reserve and miss three to four games, Rapoport added.

Edmonds suffered the injury on the first play of Arizona's 31-17 win over the San Francisco 49ers on Sunday. He was spelled by Conner, who blasted off for 173 total yards and three TDs on 26 touches. Eno Benjamin also got some run in Edmonds' wake, carrying the ball nine times for 39 yards.

It's another offensive loss for Arizona, which entered its Week 9 contest without starting quarterback Kyler Murray and receivers DeAndre Hopkins and A.J. Green. The Cardinals (8-1) could have at least Murray and Hopkins back for their Week 10 game against the Panthers, but they'll likely be without Edmonds back until Week 13 or later.

Coach Kliff Kingsbury told reporters Monday he doesn't "have a feel" yet for Murray's status against Carolina. He is waiting to see how the star QB is doing when practice resumes Wednesday. Kingsbury added that Hopkins (hamstring) and guard Justin Pugh (calf) are day to day and Green remains in the COVID protocol.

Injuries/COVID-19

• Pittsburgh Steelers coach Mike Tomlin said after Monday night's win over the Bears that receiver Chase Claypool is being evaluated for an undisclosed injury. Claypool limped off the field late in the game. More updates are expected tomorrow.
• Chicago Bears receiver Allen Robinson sustained a hamstring injury and defensive tackle Akiem Hicks suffered an ankle sprain against the Steelers, per coach Matt Nagy. Earlier in the day, Chicago activated running back off injured reserve.
• Tampa Bay Buccaneers head coach Bruce Arians told reporters that wide receiver Antonio Brown (ankle) remains in a walking boot and it does not appear he will be ready to play for their upcoming game against the Washington Football Team. Arians also said he was not confident that tight end Rob Gronkowski (back) will be available Week 10.
• Los Angeles Rams coach Sean McVay said quarterback Matthew Stafford "is good" after he sustained a "mild kind of ankle sprain" against the Titans on Sunday night. McVay also said linebacker Von Miller (ankle) is stll being considered day-to-day and will continue his rehab; his status for Week 10 is still to be determined. Rookie tight end Jacob Harris will miss the rest of the seson after tearing his ACL and MCL, McVay added.
• San Francisco 49ers right tackle Mike McGlinchey suffered a torn quad Sunday and will miss the remainder of the season, Rapoport reported. Kyle Shanahan told reporters receiver Mohamed Sanu has a knee sprain and will be out for awhile. Shanahan also noted that safety Tavon Wilson is dealing with a foot injury and is likely to land on injured reserve, WR Jalen Hurd (knee) is not expected to be available for the rest of the season and S Tarvarius Moore (Achilles) has an outside chance of returning to the team.
• Denver Broncos guard Graham Glasgow suffered a leg fracture Sunday and is out indefinitely, Rapoport reported. Denver later announced cornerback Duke Dawson has been activated off the physically unable to perform list, and the official placement of quarterback Drew Lock on the reserve/COVID-19 list. Dawson tore his ACL last December and has not played in 2021. Lock landed on the COVID list after a positive test.
• The Detroit Lions are designating backup quarterback Tim Boyle to return from injured reserve, NFL Network's Tom Pelissero reported, per a source. He has been out since undergoing thumb surgery Aug. 30. The Lions have three weeks to activate Boyle from IR. The Lions placed wide receiver Javon McKinley on practice squad injured reserve.
• Carolina Panthers quarterback Sam Darnold is undergoing an MRI on his sore shoulder, coach Matt Rhule said. Defensive lineman Brian Burns is dealing with an ankle sprain. Rhule also confirmed that center Matt Paradis will miss the rest of the season after suffering a torn ACL on Sunday. The Panthers placed Paradis and offensive tackle Cameron Erving on IR.
• Miami Dolphins receiver Will Fuller (broken finger) won't play against the Ravens, coach Brian Flores said.
• Jacksonville Jaguars quarterback Trevor Lawrence will be limited in practice this week as he deals with a low-ankle sprain.
• The Baltimore Ravens activated tight end Nick Boyle (knee) from injured reserve to the active roster, designated guard Ben Cleveland (knee) for return to practice and placed safety DeShon Elliott on IR. The Ravens listed Boyle, receivers Marquise Brown (back) and Sammy Watkins (thigh) and defensive tackle Brandon Williams (shoulder) as limited practice participants on the estimated injury report. Running back Latavius Murray (ankle) and offensive lineman Patrick Mekari (ankle) were non-participants.
• Cleveland Browns running back John Kelly and receiver Lawrence Cager were placed on the reserve/COVID-19 list due to positive tests, Pelisseri reported, per the transaction wire.
• Buffalo Bills coach Sean McDermott said he is hopeful tight end Dawson Knox (hand) and offensive tackle Spencer Brown (back) return to practice Wednesday. Cornerback Taron Johnson and running back Zack Moss remain in the concussion protocol.
• Los Angeles Chargers cornerback Asante Samuel Jr. remains in the concussion protocol, per coach Brandon Staley.
• Minnesota Vikings safety Harrison Smith, linebacker Ryan Connelly and offensive tackle Timon Parris were placed on the reserve/COVID-19 list due to positive tests, Pelisseri reported, per the wire. Smith was placed on the list prior Sunday's game versus Baltimore.

Roster moves

• The Las Vegas Raiders are releasing former first-round cornerback Damon Arnette, Pelissero reported. Raiders GM Mike Mayock confirmed the move, as well as the team's acquisition of wide receiver DeSean Jackson.
• The Cleveland Browns officially placed wideout Odell Beckham on waivers on Monday.
• The New England Patriots waived offensive lineman James Ferentz, Pelissero reported, per the wire.
• The Detroit Lions waived tight end Darren Fells and wide receiver Tom Kennedy and signed tight end Brock Wright to the active roster.
• The New York Jets are releasing veteran punter Thomas Morstead, who will be subject to waivers. The vet's cut means Braden Mann, who was designated to return from injured reserve Oct. 27, is set to see the field in Week 10.
• The Baltimore Ravens signed safety Jordan Richards to the practice squad.
• The Jacksonville Jaguars signed wide receiver John Brown and running back Jordan Wilkins to their practice squad and released running back Kerrith Whyte from the practice squad.